中医药调控糖尿病常见并发症bax表达的实验研究述评

Review of experimental studies of bax expressions of the regulation of traditional Chinese medicine on common complications of diabetes mellitus

关键词:  糖尿病  中医药  bax  实验研究

Key words:  Diabetes mellitus  traditional Chinese medicine  bax  experimental research  review

摘要:

糖尿病及其并发症发病机制复杂，尚未完全阐明。研究发现靶细胞的损伤、凋亡，进而导致的组织损伤，是糖尿病各种并发症发生、发展的重要因素。Bax是重要的细胞凋亡因子，其表达水平的异常，与糖尿病各种并发症发生、发展密切相关。研究发现单味中药或复方，可通过降低糖尿病并发症靶细胞中bax表达水平，改善靶细胞功能，保护靶细胞结构，降低靶细胞凋亡率，从而延缓糖尿病并发症的发生发展。现对近年来中医药调控糖尿病常见并发症中bax表达的相关实验研究进行述评，以飨同道。

Abstract:

The complicated pathogenesis of diabetes mellitus and its complications had not been fully clarified, Further studies found that target cells damage and apoptosis can lead to the tissue damage important factors in the occurrence and development of diabetes mellitus and its complications. Bax is an important apoptosis factor, and its expression levels are closely related to the occurrence and development of diabetes mellitus and its complications. Studies found that single herbs or decoctions, can reduce the expression levels of bax in target cells in diabetes mellitus and its complications, improve the function of target cells, protect the cell structure, and reduce the rate of apoptosis of target cells, thus delay the occurrence and development of diabetes mellitus and its complications. The purpose of this paper is that to review the experimental studies of the expressions of bax of traditional chinese medicine controling the common complications of diabetes mellitus which aim at sharing some views for fellows.