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| 马钱子毒性及制剂技术减毒增效方法研究进展 |
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郭盼1,2, 李新悦1,2, 张兵1,2, 卢鹏1,2, 李佳玮1,2, 刘志东1,2
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1.天津中医药大学, 现代中药发现与制剂技术教育部工程中心, 天津 300193;2.天津中医药大学, 天津市现代中药重点实验室-省部共建国家重点实验室培育基地, 天津 300193
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| 摘要: |
| 马钱子为临床常用中药，广泛用于风湿顽痹，麻木瘫痪，类风湿性关节痛等疾病，临床疗效确切，但因容易发生中毒反应使其应用受到了诸多限制，因此马钱子的减毒增效研究具有重要意义。本文对马钱子的药理作用、毒性以及通过制剂技术减毒增效的方法加以综述，为今后深入研究提供了相关依据。 |
| 关键词: 马钱子 化学成分 药理作用 毒性 减毒增效 制剂技术 |
| DOI：10.11656/j.issn.1673-9043.2018.03.05 |
| 分类号:R285.5 |
| 基金项目: |
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| Research progress on toxicity and attenuated synergies by pharmaceutics technology of Strychnos |
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GUO Pan1,2, LI Xinyue1,2, ZHANG Bing1,2, LU Peng1,2, LI Jiawei1,2, LIU Zhidong1,2
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1.Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| Strychnos has exact clinical efficacy, and is widely used in treating rheumatism, numbness paralysis, rheumatoid arthritis and other diseases. However, the application is limited due to the toxic reactions. Therefore, to attenuate the toxicity and enhance the efficiency will be of great significance to strychnos. In this paper, the pharmacological effect, toxicity and the method of attenuating the toxicity and enhancing the efficiency through pharmaceutics technology were summarized, which provided the basis for further study. |
| Key words: strychnos chemical constituents pharmacological effect toxicity attenuated synergies pharmaceutics technology |
