冬夏使用补肾中药治疗绝经后骨质疏松症临床研究

The effect of the treatment in winter and summer on estradiol and melatonin level for postmenopausal osteoporosis with traditional Chinese medicine which invigorate the kidney and essence replenishment

关键词:  肾应冬  肾主骨  绝经后骨质疏松症  择时治疗  临床研究

Key words:  kidney corresponding with the winter  kidneys governing bone  postmenopausal osteoporosis  chrono-medication  clinical research

摘要:

[目的]探讨基于"肾应冬"、"肾主骨"理论，冬季进行中药干预治疗绝经后骨质疏松症是否存在优势。[方法]选取绝经后骨质疏松症病例64例，随机分为中药组33例与对照组31例。两组治疗时间均由立冬节气至大寒节气共75 d，其中中药组使用二仙汤加减自拟方配合常规西药治疗，对照组使用常规西药治疗，大寒节气后两组均采用常规西药治疗。[结果]治疗后全年随访中，中药组血清雌二醇上升值显著低于对照组（P<0.05），中药组血清褪黑素上升值显著低于对照组（P<0.05）。[结论]冬夏两季使用补肾益精中药治疗绝经后骨质疏松症均具一定疗效，且疗效存在季节性差异，冬季用药较夏季存在优势。

Abstract:

[Objective] To investigate whether there is an advantage in the treatment of postmenopausal osteoporosis in winter with traditional Chinese Medicine which treatment based on the theory of "kidney corresponding with winter" and "the kidney being in charge of bone".[Methods] Review 64 cases of postmenopausal osteoporosis,divided them into experimental group and control group. The experimental group 32 cases were treated with TCM which invigorate the kidney and essence replenishment,while the control group 32 cases were treated with Caltrate D. Observed E2 and MT level annual indications.[Results] Analysis of the level of estradiol and melatonin changes of postmenopausal osteoporosis patients after treatment.[Conclusion] Based on the theory of kidneys governing bone and kidney corresponding with the winter,the theory of taking medicine in accordance with suitable time has a certain extent clinical guiding significance.