急性胃肠损伤生物标志物研究及诊治进展

Progress of biomarkers,diagnosis and treatment for acute gastrointestinal injury

关键词:  急性胃肠损伤  生物学标志物  诊治  进展

Key words:  acute gastrointestinal injury  biological markers  diagnosis and treatment  progress

摘要:

近年来，危重患者胃肠功能障碍的问题已受到越来越多临床医生的广泛关注，因此在2012年欧洲重症监护医学学会腹部问题工作组对危重症患者的胃肠功能进行了规范化阐述。本文就急性胃肠损伤（AGI）的定义、诊断、新型生物学标记物、治疗进展进行了综述，认为AGI的提出对早期急性胃肠损伤患者的及时干预及改善预后有着重要意义。一些新型生物学标志物能否应用于临床尚需进一步验证及临床观察研究。中医药从患者整体观出发，防治AGI具有其一定的特色，中医内服及外治疗法对于降低患者病死率、提高其近期和远期的存活率、减少患者个人和社会的医疗费用等方面有着积极作用，值得进一步研究。

Abstract:

In recent years, the problem of critically ill patients with gastrointestinal dysfunction has been paid attention by more and more clinical doctors. So, in 2012 the working group on abdominal problems (WGAP) of European society of intensive care medicine (ESICM) normalize the gastrointestinal function of critically ill patients. In this paper, the definition, diagnosis and new type of biological markers and progress in treatment of acute gastrointestinal injury (AGI) were summarized. We believe that AGI's proposal is of great significance for the timely intervention and the improvement of prognosis of patients with early acute gastrointestinal injury. Whether some new biomarkers can be applied in clinical studies need further verification and clinical observation. From a patient's overall view of Chinese medicine, prevention and treatment of AGI has its certain characteristics. Traditional Chinese medicine and external therapy have positive effects on reducing the mortality rate of patients and reducing the patients' personal and social medical expenses, which is worthy of further study.