中医体质可调论应用于卵巢癌防治的探索性研究——基于34例卵巢癌患者体质类型与糖类抗原CA199、CA125的相关性分析

An exploratory research on the traditional Chinese medicine constitutional adjustment theory's application in ovarian cancer: based on the correlation analysis of 34 ovarian cancer patients' traditional Chinese medicine constitution types and CA125,CA199

关键词:  卵巢癌  中医体质  微观因子  体质可调论

Key words:  ovarian cancer  traditional Chinese medicine constitution  micro factors  adjustment of traditional Chinese medicine constitution

摘要:

[目的] 在揭示中医体质作用于卵巢癌的微观机制基础上，对中医体质可调论应用于卵巢癌防治进行初步的探索性研究。[方法] 利用中医体质分类和判定表，于2015年3—9月的哈尔滨医科大学附属第三医院妇科病房，对卵巢癌患者进行结构性访谈，收集到34位卵巢癌患者的体质类型数据和癌胚抗原（CA）199与CA125的检测值，以中医体质分类和判定表的问题作为自变量，构建了以CA199、CA125分别作为因变量的测量模型1和测量模型2，然后进行回归分析。[结果] 体质类型方面，34位患者中，倾向或属于阳虚质26例，倾向或属于阴虚质10例，倾向或属于气虚质19例，倾向或属于痰湿质9例，倾向或属于湿热质6例，倾向或属于血瘀质12例，倾向或属于特禀质1例，倾向或属于气郁质19例；测量模型的回归分析方面，测量模型1的调整R²为0.999，方差分析的F统计量值为879.420（P=0.025），整体拟合程度较好；测量模型2的调整R²为0.682，方差分析的F统计量为3.216（P=0.419），整体拟合度非常不足。由于存在多重共线性，对测量模型1进行了修正，其调整R²为0.819，方差分析的F统计量为10.327（P<0.05），整体拟合度很高，变量的相关系数在0.05的水平上显著。[结论] 第一，兼夹体质广泛存在；第二，微观因子可能存在部分中介作用；第三，为中医体质可调论在卵巢癌防治中的实际应用、可操作性以及体质调整效果评估提出了一个可行办法。

Abstract:

[Objective] Based on revealing the micro mechanism of how traditional Chinese medicine(TCM) contitution affects ovarian cancer,this paper intense to make exploratory research on the TCM constitutional adjustment theory's application in ovarian cancer.[Methods] By using "Chinese medicine constitution classification and decision table",the sample data of 34 ovarian cancer patients is collected in department of gynaecology ward of the Third Affiliated Hospital of Harbin Medical University,as well as the data of CA199 and CA125. To make regression analysis,model 1 with CA199 as dependent variable and model 2 with CA125 as dependent variable have been built,in which the questions in "Chinese medicine constitution classification and decision table" are independent variables.[Results] As to constitution types,all of the patients are mixed biased constitutions. As to the regression analysis of the two models,in model 1,its adjusted R² is 0.999,F-statistics is 879.420(P=0.025),so that the overall fitting degree of regression equations of model 1 is acceptable. In model 2,its adjusted R² is 0.682,F-statistics is 3.216(P=0.419),so that the overall fitting degree of regression equations of model 2 is unacceptable. Due to the multicollinearity,model 1 is modified. In modified model 1,its adjusted R² is 0.819,F-statistics is 10.327(P<0.05). Thus,the overall fitting degree of regression equations of modified model 1 is acceptable.[Conclusion] On one hand,mixed constitutions widely exist. On the other hand,micro factor may partly explain the pathological of ovarian cancer in the perspective of TCM constitution,which shows a way to put adjustable theories of TCM constitution into use and research on curing ovarian cancer.