病证结合模式下腹泻型肠易激综合征实验动物模型的研究进展

Research progress on experimental animal model of diarrhea-predominant irritable bowel syndrome combining disease and syndrome

关键词:  腹泻型肠易激综合征  病证结合  动物模型  综述

Key words:  diarrhea-predominant irritable bowel syndrome  combination of prescription and syndrome  animal model  review

摘要:

从病证结合角度对功能性肠病进行诊治，体现了中医学辨证论治的特色。中医临床与基础实验的连接需要病证相结合的动物模型。因此，构建符合临床特征的病证结合模式下腹泻型肠易激综合征（IBS-D）动物模型，有利于人们进一步认识本病的病因及发病机制，从而发挥中医对本病的辨证优势。目前多数学者常应用多因素复合法制备腹泻型肠易激综合征动物模型，并且国内常见的病证结合模式下的IBS-D动物模型有肝郁脾虚型、脾肾阳虚型和脾胃湿热型3类，文章就病证结合模式下IBS-D实验动物模型的研究进展进行综述，以期为中医实验研究动物模型的制备提供依据。

Abstract:

The diagnosis and treatment of functional bowel disease from the perspective of combination of disease and syndrome reflects the characteristics of syndrome differentiation and treatment of traditional Chinese medicine (TCM). The connection of TCM clinical and basic experiments requires an animal model combining disease and syndrome. Therefore, constructing an animal model of diarrhea-predominant irritable bowels yndrome (IBS-D) under the mode of combining disease and syndrome in accordance with clinical characteristics will help people to further understand the etiology and pathogenesis of the disease, so as to give play to the syndrome differentiation advantage of TCM. At present, most scholars often use a multi-factor compound method to prepare diarrhea-predominant irritable bowel syndrome animal models. The common IBS-D animal models in the combination of disease and syndrome models in China include liver depression and spleen deficiency, spleen and kidney yang deficiency, and spleen and stomach damp-heat. This article reviews the research progress of IBS-D experimental animal models under the combination mode of disease and syndrome, with a view to providing a basis for the preparation of experimental animal models of TCM.