雷火灸治疗盆腔炎性疾病后遗症疗效及对血清Caspase-3、sFas影响

Thunder fire moxibustion for sequelae of pelvic inflammatory disease: clinical efficacy and influence on serum Caspase-3 and sFas

关键词:  雷火灸  盆腔炎性疾病后遗症  半胱氨酸蛋白酶-3  可溶性凋亡相关因子

Key words:  thunder fire moxibustion  sequelae of pelvic inflammatory disease  Caspase-3  soluble factor associated suicide

摘要:

[目的] 探讨雷火灸治疗盆腔炎性疾病后遗症的疗效及对血清半胱氨酸蛋白酶-3（Caspase-3）、可溶性凋亡相关因子（sFas）的影响。[方法] 将65例患者随机分为对照组32例及治疗组33例，对照组予常规西药治疗，治疗组在对照组基础上予雷火灸治疗。统计两组临床疗效，观察视觉模拟评分法（VAS）评分、盆腔积液深度及炎性包块直径、血清肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）、Caspase-3及sFas水平变化。[结果] 治疗组有效率高于对照组（P<0.05）。治疗后，治疗组VAS评分低于对照组（P<0.05）；治疗组盆腔积液深度、炎性包块直径小于对照组（P<0.05）；治疗组血清TNF-α、CRP水平低于对照组（P<0.05）；治疗组血清Caspase-3水平高于对照组（P<0.05），血清sFas水平低于对照组（P<0.05）。[结论] 雷火灸治疗盆腔炎性疾病后遗症疗效显著，有利于改善疼痛症状，促进盆腔积液及炎性包块吸收，降低炎性因子水平，调节血清Caspase-3、sFas水平。

Abstract:

[Objective] To observe the curative effect and influence on serum Caspase-3 and soluble factor associated suicide(sFas) of thunder fire moxibustion for sequelae of pelvic inflammatory disease.[Methods] The 65 cases were randomly divided into control (32 cases) and treatment group (33 cases). The control group was given conventional western medicine. Based on conventional Western medicine, the treatment group was given thunder fire moxibustion. The curative effect was evaluated. The changes of visual analogue scale(VAS), pelvic effusion depth, inflammatory mass diameter, and serum level of tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), Caspase-3 and sFas were compared.[Results] The effective rate in treatment group were higher than in control group(P<0.05). After treatment, VAS score in treatment group was lower than in control group(P<0.05), pelvic effusion depth and inflammatory mass diameter in treatment group were lower than in control group(P<0.05), serum level of TNF-α and CRP in treatment group was lower than in control group(P<0.05), serum level of Caspase-3 in treatment group was higher than in control group(P<0.05), and serum level of sFas in treatment group was lower than in control group(P<0.05).[Conclusion] Thunder fire moxibustion for sequelae of pelvic inflammatory disease had definite clinical effect. It can relieve pain symptom, promote the absorption of pelvic effusion and inflammatory mass, reduce serum level of inflammatory factors, and regulate serum level of Caspase-3 and sFas.