通肺化痰汤加减对痰热郁肺型COPD急性加重期患者血清LCN1和LCN2水平的影响

Effect of Tongfei Huatan Decoction on serum LCN1 and LCN2 levels in patients with acute exacerbation of COPD of phlegm heat stagnation type

关键词:  通肺化痰汤  慢性阻塞性肺疾病急性加重期  痰热郁肺证  脂质运载蛋白1  脂质运载蛋白2

Key words:  Tongfei Huatan Decoction  AECOPD  phlegm heat damming lung syndrome  LCN1  LCN2

摘要:

[目的] 观察通肺化痰汤加减对痰热郁肺型慢性阻塞性肺疾病急性加重期（AECOPD）患者的临床疗效及对血清LCN1和LCN2水平的影响。[方法] 选取痰热郁肺型AECOPD患者80例，应用随机数字表法分为对照组和治疗组（每组40例），两组患者均应用吸氧、抗感染等基础治疗，对照组使用茶碱缓释片、沙美特罗替卡松粉吸入剂，治疗组在对照组基础上加用通肺化痰汤加减，治疗结束后比较两组患者临床疗效、肺功能、肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-8及脂质运载蛋白（LCN）1、LCN2水平的变化。[结果] 治疗后，治疗组总有效率（90%）高于对照组总有效率（72.5%，P<0.05），两组肺功能水平较治疗前升高，治疗组高于对照组（P<0.05）；治疗后TNF-α、IL-8水平较治疗前降低，治疗组低于对照组（P<0.05）；治疗后LCN1、LCN2水平较治疗前降低，治疗组低于对照组（P<0.05），治疗过程中未发生不良反应。[结论] 通肺化痰汤对治疗痰热郁肺型AECOPD患者疗效显著，安全性高，可明显改善患者肺功能，降低血清TNF-α、IL-8、LCN1、LCN2水平，提高临床疗效。

Abstract:

[Objective] To observe the clinical effect of Tongfei Huatan Decoction on the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) of phlegm heat stagnation type and the effect on the levels of serum LCN1 and LCN2.[Methods] The 80 patients with acute exacerbation of AECOPD were randomly divided into two groups:the control group and the treatment group (40 cases in each group). The two groups were treated with basic treatment such as oxygen inhalation and anti infection. The control group was treated with theophylline sustained-release tablets and salmeterol ticasone powder inhalation. The treatment group was treated with Tongfei Huatan Decoction on the basis of the control group. After the treatment, the two groups were compared with each other changes of bed efficacy, lung function, TNF-α, IL-8, LCN1 and LCN2 levels.[Results] After treatment, the total effective rate of the treatment group (90%) higher than that of the control group (72.5%, P<0.05). After treatment, the pulmonary function of the two groups was higher than that of the control group (P<0.05);the levels of TNF and IL-8 were lower than that of the control group (P<0.05);after treatment, the levels of LCN1 and LCN2 were lower than that of the control group (P<0.05). There were no adverse reactions during the treatment.[Conclusion] Tongfei Huatan Decoction was effective and safe in the treatment of acute exacerbation of COPD of phlegm heat stagnation type. It can obviously improve the lung function, reduce the levels of TNF-α, IL-8, LCN1 and LCN2, and improve the clinical effect.