基于中医传承辅助平台探讨王金贵教授治疗痉挛性斜颈的用药规律

Study on the medication rule of Professor WANG Jingui in the treatment of spastic yorticollis based on traditional Chinese medicine inheritance support system

关键词:  痉挛性斜颈  数据挖掘  用药规律  中医传承辅助平台  王金贵

Key words:  spastic torticollis  data mining  the law of medication application  traditional Chinese medicine inheritance support system  WANG Jingui

摘要:

分析王金贵教授治疗痉挛性斜颈的用药规律、组方特点及学术思想，并为治疗提供新的思路参考。[方法] 双人筛选录入信息，将王金贵教授治疗痉挛性斜颈门诊处方录入“中医传承辅助平台管理系统（V2.5）”并建立相关数据库，采用关联规则分析法、改进的互信息法、复杂系统熵聚类、无监督的熵层次聚类等高级数据挖掘方法，对数据库进行四气五味、归经分布及用药频次统计、药物组合及组方规律分析。[结果] 筛选治疗痉挛性斜颈的处方152首，涉及129味药物，累计使用频次2 842次，柴胡、炙甘草、当归、茯苓、远志、石菖蒲为高频药物，肝经、脾经为高频归经，基本经验方为定痫丸、桂枝加葛根汤及越鞠丸等。[结论] 通过数据挖掘，总结王金贵教授治疗痉挛性斜颈是在舒肝健脾、开窍醒神、解肌止痉的基础上重视辨证用药与临床加减，创建病证结合的治疗体系，为临床及进一步科学研究提供数据支撑。

Abstract:

[Objective] This paper analyzes the medication rules, prescription characteristics and academic thoughts of Professor WANG Jingui in the treatment of spastic torticollis, and provides a new reference for the treatment of the disease.[Methods] By two people making the information input, the outpatient prescriptions of Professor WANG Jingui for treating spastic torticollis were input into the "Traditional Chinese Medicine Inheritance Support System (V2.5)" and the relevant database was established. Advanced data mining methods, such as association law analysis, improved interactive information method, complex system entropy clustering and unsupervised entropy hierarchical clustering method, were used to analyze the database for four characters (FC) and five tastes (FT), meridian distribution and medication frequency statistics, drug combination and prescription rule analysis.[Results] The 152 prescriptions were screened for the treatment of spastic torticollis, which involved 129 drugs, with a cumulative frequency of 2 842 times. Bupleuri Radix, roasted Glycyrrhizae Radix et Rhizoma, Angelicae Sinensis Radix, Poria, Polygalae Radix, Acori Tatarinowii Rhizoma were high-frequency traditional Chinese medicinal materials, liver meridian and spleen meridian were high-frequency meridian tropism, which were basically for Decoction for Eplepsy, Guizhi Gegen Decoction and Yueju Pills and other drugs.[Conclusion] Through data mining, it comes to a conclusion that Professor WANG Jingui treats spasmodic torticollis on the basis of soothing the liver and strengthening the spleen, opening the orifices and waking up the mind, relieving muscles and stopping spasm, and attaches importance to dialectical selection, clinical addition and subtraction, and creates a governance system combining disease and syndrome, so as to provide data support for clinical and further scientific research.