醒脑静注射液治疗缺血性中风适应症状群的真实世界研究

Real-world study on the adaptive symptom cluster of Xingnaojing Injection in the treatment of ischemic stroke

关键词:  醒脑静注射液  缺血性中风  中成药  适应症状群  真实世界研究

Key words:  Xingnaojing Injection  ischemic stroke  Chinese patent medicine  adaptive symptom cluster  real-world study

摘要:

[目的] 基于真实世界医疗数据，分析醒脑静注射液治疗缺血性中风的适应症状群。[方法] 以电子住院记录为资料开展回顾性分析，根据治疗前后病情变化将病例分为有效组与无效组，通过χ²检验、二元Logistic回归分析确定适应症状群相关指标，并将结果可视化为列线图。[结果] 红舌、滑脉对醒脑静疗效起正向影响，具备该特征的患者有效性较好；神疲、面色萎黄、少苔对醒脑静疗效起负向影响，具备该特征的患者有效性较低。[结论] 明确中成药临床适应症状群可以指导医师合理用药，利用真实世界医疗数据可以成为研究中成药临床适应症状群的一种模式。

Abstract:

[Objective] Based on real-world medical data,analyze the adaptive symptom cluster of Xingnaojing Injection in the treatment of ischemic stroke. [Methods] A retrospective analysis was carried out using electronic hospital records as data. The cases were divided into effective group and ineffective group according to the changes in the condition before and after treatment,and the related indexes of adaptive symptom cluster were determined by χ² test and binary logistic regression analysis,and the results were visualized as a nomogram. [Results] Red tongue and slippery pulse had a positive effect on the curative effect of Xingnaojing Injection,and patients with this feature were more effective. Fatigue,pale complexion,and less tongue coating have a negative impact on the curative effect of Xingnaojing Injection,and patients with this feature had poor effectiveness. [Conclusion] Clarifying the clinically adaptive symptom clusters of Chinese patent medicines can guide physicians in the rational use of drugs,and the use of real-world medical data can become a model for studying the clinically adaptive symptom clusters of Chinese patent medicines.