| 摘要: |
| [目的] 系统评价真针与假针对无先兆偏头痛患者脑功能活动的影响。[方法] 检索PubMed、中国知网、万方数据知识服务平台和维普期刊资源整合服务平台，检索各数据库建库至2022年4月7日针刺治疗无先兆偏头痛的文献，以功能性磁共振成像（fMRI）为观察指标，收集针刺对无先兆偏头痛患者脑功能影响的文献，汇总真针与假针对无先兆偏头痛患者的脑功能影像数据并进行体素Meta分析，得出真针与假针引起无先兆偏头痛患者脑功能变化的一般规律。[结果] 共检索到文献640篇，其中8篇文献符合纳入标准，共纳入425例受试者，对8项研究进行体素Meta分析，结果显示真针升高左前扣带回/旁扣带回、左小脑半球小叶、右脑岛、左额下回眶部、右侧辅助运动区、右中央前回、左角回、右角回、左颞上回的脑功能，降低小脑蚓的脑功能（P＜0.05）。真针组与假针组比较，显著改变的共性脑区定位于脑功能降低的右枕中回。[结论] 初步认为真针与假针对无先兆偏头痛患者脑功能活动的影响不同，引出的中枢响应特征不同，真针激活脑区更多。假针影响的脑区需要更多高质量研究进一步证实。 |
| 关键词: 偏头痛 针刺 功能性磁共振成像 Meta分析 随机对照试验 |
| DOI：10.11656/j.issn.1673-9043.2023.05.08 |
| 分类号: |
| 基金项目:国家重点研发计划资助项目(2019YFC1709703);首都卫生发展科研专项青年优才项目(首发2020-4-2236);北京市教育委员会科技计划一般项目(KM202110025005);国家自然科学基金项目(82074179);中国科协青年人才托举工程项目(2019-2021ZGZJXH-QNRC001)。 |
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| Meta-analysis of the effects of true and false acupuncture on functional brain activity in migraine patients |
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CHEN Qiuyi, LIU Lu, YANG Xin, LI Bin
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Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
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| Abstract: |
| [Objective] Systematic evaluation of the effects of acupuncture and sham acupuncture on brain functional activity in patients with migraine without aura. [Methods] PubMed,CNKI,Wanfang database and VIP journal resource integration service platform were searched for literatures on acupuncture treatment of migraine without aura from the establishment of each database to April 7,2022. FMRI was used as an observation indicator to collect literatures on the effects of acupuncture on brain function of migraine without aura patients. The brain function imaging data of migraine patients without aura were summarized and voxel Meta-analysis was conducted to find the general rule of brain function changes caused by migraine patients without aura by acupuncture and sham acupuncture. [Results] A total of 640 literatures were retrieved,8 literatures met the inclusion criteria,and a total of 425 subjects were included. After voxel Meta-analysis of 8 studies,The results showed that true acupuncture increased the brain function of left anterior cingulate gyrus/paraccingulate gyrus,and decreased the brain function of cerebellum vermiS(P<0.05). Compared with sham acupuncture group,the brain region of the acupuncture group was located in the right middle occipital gyrus with reduced brain function. [Conclusion] It is initially believed that the acupuncture and sham acupuncture have different effects on brain functional activity in patients with migraine without aura,and the central response characteristics are different,and the real needle activates more brain areas. More high-quality studies are needed to confirm the brain regions affected by the sham acupuncture. |
| Key words: migraine acupuncture fMRI Meta-analysis randomized controlled trial |
