从“肺-肠”轴角度探讨肠道菌群与过敏性鼻炎的关系

Relationship between intestinal micro-ecology and allergic rhinitis based on lung-Gut Axis

关键词:  肺-肠轴  肺肠关系  肠道菌群  过敏性鼻炎  肺与大肠相表里

Key words:  lung-gut axis  relationship between lung and gut  gut flora  allergic rhinitis  interior-exterior relationship between the lung and large intestine

摘要:

过敏性鼻炎属于全球高发的气道变应性疾病，较多人群深受其影响，关于其更安全有效的治疗方式仍不断被探寻与挖掘。近年来关于肠道微生态与肺部疾病的相互关系被深入研究，文章基于肺肠关系，结合中医“肺与大肠相表里”理论，并从西医胚胎发育、菌群微环境、内分泌代谢、黏膜免疫等角度探讨肺-肠关系，在此基础上，认为肠道菌群可从细胞因子免疫平衡、机体黏膜等方面影响过敏性鼻炎的发生发展，以期为临床治疗过敏性鼻炎提供更多思路。

Abstract:

Allergic rhinitis is a high incidence airway allergic disease in the world，and many people are deeply affected by it. More safe and effective treatment methods are still being explored. In recent years，with the in-depth study of the relationship between intestinal micro-ecology and pulmonary diseases，it has been confirmed that the colonization of intestinal flora in infancy affects the occurrence and development of allergic diseases. However，there are still few studies on intestinal flora and allergic rhinitis. The article is based on the relationship between lung and intestine，goes deep into the theoretical connotation of “the interior-exterior relationship between the lung and large intestine” in Chinese medicine，and explores the relationship between lung and intestine from the perspectives of western medicine embryo development，microbial micro-environment，endocrine metabolism，mucosal immunity，etc. On this basis，it expounds that intestinal flora affects the occurrence and development of allergic rhinitis from the perspectives of immunity，inflammation，etc.，providing more possibilities for clinical treatment of allergic rhinitis.