尿毒清颗粒辅助治疗对糖尿病肾病糖代谢指标及炎症反应的影响

Effects of Niaoduqing Granule on glucose metabolism and inflammatory reaction in diabetes nephropathy

关键词:  尿毒清颗粒  糖尿病肾病  糖代谢  炎症反应

Key words:  Niaoduqing Granule  diabetes nephropathy  sugar metabolism  inflammatory reaction

摘要:

[目的] 研究尿毒清颗粒辅助治疗对糖尿病肾病糖代谢指标及炎症反应的影响。[方法] 回顾性选取2022年7月—2023年9月石家庄市第二医院收治的57例采用常规疗法进行治疗的糖尿病肾病患者作为对照组，并选取同期收治的57例在常规治疗基础上合并尿毒清颗粒辅助治疗的糖尿病肾病患者作为治疗组。比较两组患者治疗前后的糖代谢指标、炎症因子指标、肾功能指标，并分析患者治疗后的糖代谢指标、炎症因子指标与治疗后肾功能指标的相关性。记录治疗期间的肝功能指标及发生的药物不良反应。[结果] 治疗前两组患者各指标比较，差异无统计学意义（P＞0.05）。治疗后治疗组患者的空腹血糖（FPG）、餐后2 h血糖（2 hPG）、糖化血红蛋白（HbA1c）、超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、血肌酐（Scr）、尿素氮（BUN）、尿微量白蛋白与尿肌酐比值（ACR）低于对照组（P＜0.05）。114例患者治疗后的糖代谢指标（FPG、2 hPG、HbA1c）、炎症因子指标（hs-CRP、IL-6、TNF-α）分别与治疗后的Scr、BUN、ACR呈正相关（P＜0.05）。治疗前后两组患者的天氡氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）比较，差异无统计学意义（P＞0.05），且均未出现不良反应。[结论] 对糖尿病肾病患者采用尿毒清颗粒辅助治疗，能够有效改善其糖代谢指标，减轻炎症反应，有助于改善患者肾功能，并且具有良好的安全性。

Abstract:

[Objective] To study the effect of Niaoduqing Granule on glucose metabolism and inflammatory reaction in diabetes nephropathy. [Methods] Retrospectively select 57 patients with diabetes nephropathy who received conventional treatment from July 2022 to September 2023 as the control group，and select 57 patients with diabetes nephropathy who received conventional treatment plus auxiliary treatment of Niaoduqing Granule at the same time as the study group. Compare the glucose metabolism indicators，inflammatory factor indicators，and renal function indicators before and after treatment between two groups，and analyze the correlation between glucose metabolism indicators，inflammatory factor indicators，and renal function indicators after treatment. Record liver function indicators and adverse drug reactions during treatment. [Results] There was no statistically significant difference in various indicators before treatmenｔ（P＞0.05）. After treatment，the FPG，2 hPG，HbA1c，hs-CRP，IL-6，TNF-α，Scr，BUN，and ACR of the study group were lower than those of the control group（P＜0.05）. The glucose metabolism indicatoｒs（FPG，2 hPG，HbA1c) and inflammatory factor indicatoｒs（hs-CRP，ＩL-6，TNF-α） ｏｆ 114 patients after treatment were positively correlated with Scr，BUN，and ACR after treatment（P＜0.05）. There was no statistically significant differencｅ（P＞0.05） in ALT and AST before and after treatment in both groups，and no adverse reactions occurred. [Conclusion] The auxiliary treatment of Niaoduqing Granule for patients with diabetes nephropathy can effectively improve the indicators of glucose metabolism，reduce inflammatory reaction，help improve the renal function of patients，and has good safety.