中药治疗膝骨关节炎的药理学机制研究

Pharmacological mechanisms of traditional Chinese Medicine in the treatment of knee osteoarthritis

关键词:  膝骨关节炎  中药  药理学  分子机制

Key words:  knee osteoarthritis  traditional Chinese medicine  pharmacology  molecular mechanism

摘要:

膝骨关节炎（KOA）为临床常见关节退行性疾病，病程反复、致残率高，严重影响患者的生活质量。既往研究表明中药在治疗KOA方面具有独特的优势，其疗效确切且具备较高安全性，但其具体治疗机制仍待探索。网络药理学“多成分-多靶点-多通路-多疾病”研究方式与中医“辨证论治”理论吻合，为揭示中药治疗KOA机制提供思路。文章系统梳理网络药理学在中药治疗KOA药效物质基础与潜在分子机制中的应用，展望未来网络药理学在中药治疗KOA中研究方向，为揭示中药治疗KOA科学内涵提供新的视角和有力工具，进一步推进中医药现代化发展。

Abstract:

Knee osteoarthritis(KOA) is a common degenerative joint disease encountered in clinical practice,characterized by recurrent episodes and a high disability rate,which significantly impacts patients' quality of life. Previous studies have demonstrated that traditional Chinese medicine(TCM) possesses unique advantages in treating KOA,with definite efficacy and high safety. However,the specific mechanisms underlying the therapeutic effects of TCM in KOA remain to be explored. The research paradigm of network pharmacology,characterized by "multi-component,multi-target,multi-pathway,and multi-disease," aligns well with the theory of "syndrome differentiation and treatment" in TCM,offering a new approach to unravel the mechanisms of TCM in treating KOA. This paper systematically reviews the application of network pharmacology in elucidating the pharmacological material basis and potential molecular mechanisms of TCM in treating KOA and anticipates future research directions in this field. Additionally,it provides a new perspective and a powerful tool for unveiling the scientific connotations of TCM in treating KOA,further promoting the modernization of TCM.