中医药通过多维调控干细胞发挥抗抑郁效应的研究进展

Multidimensional regulatory mechanisms of traditional Chinese medicine in stem cell modulation for antidepressant efficacy：research progress

关键词:  抑郁症  干细胞  中医药  神经再生  神经递质  神经炎症

Key words:  depression  stem cells  traditional Chinese medicine  nerve regeneration  neurotransmitters  neuroinflammation

摘要:

抑郁症作为一种全球性高发的精神障碍性疾病，其病理机制涉及神经炎症、单胺类神经递质失衡、突触可塑性异常及下丘脑-垂体-肾上腺（HPA）轴功能紊乱等多重因素。传统抗抑郁药物存在疗效不稳定、药物依赖、成骨抑制等局限，亟需探索新型治疗策略。近年来，干细胞凭借其自我更新、多向分化及归巢效应等特性，在抑郁症治疗中展现出独特潜力。该文章系统综述了干细胞通过促发神经、平衡递质及免疫调节等多个方面发挥抗抑郁作用的核心机制，并探讨了中医药通过多向调控干细胞功能发挥抗抑郁效应的可行性，为抑郁症的治疗提供新的思路与理论依据。

Abstract:

Depression，a globally prevalent mental disorder，involves multifaceted pathological mechanisms such as neuroinflammation，imbalance of monoamine neurotransmitters，abnormal synaptic plasticity，and dysfunction of the hypothalamic-pituitary-adrenal axis. Conventional antidepressants face limitations，including unstable efficacy， drug dependence，and osteogenic suppression，necessitating the exploration of novel therapeutic strategies. In recent years，stem cells have demonstrated unique potential in depression treatment due to their properties of self-renewal， multipotent differentiation，and homing effects. This article systematically reviews the core mechanisms by which stem cells exert antidepressant effects through neuronal regeneration， neurotransmitter balance， and immunomodulation. Additionally，it explores the feasibility of Traditional Chinese Medicine（TCM）in modulating stem cell functions to alleviate depressive symptoms，aiming to provide innovative insights and theoretical foundations for depression treatment.