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| Effect of Huoxue Huayu Injection on the Expression of CD11b/CD18 in Lung Tissue of Rats with Severe Acute Pancreatitis |
| Hits 1316 Download times 976 Received:January 18, 2002 |
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| DOI
10.11656/j.issn.1673-9043.2002.02.23 |
| Key Words
SAP;CD11b/CD18;Lung;Pancreas;Rat |
| Author Name | Affiliation | | Zhang Yanjun | Department of Chinese Materia Medica, Tianjin University of TCM, Tianjin 300193 | | Zhao Liangen | 天津市中西医结合急腹症研究所 300100 | | Wu Xianzhong | 天津市中西医结合急腹症研究所 300100 |
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| Abstract
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| Objective: To investigate the effect of Huoxue Huayu Injection(HHI-Ⅰ) on the expression of CD11b/CD18 in lung tissue of rats with severe actue pancreatitis(SAP).Methods: Wistar rats were randomly divided into 4 groups,each containing 10,50,50 and 50 rats.1.Sham operation group.2.Model group.3.Treatment group.Intravenously HHI-Ⅰ,ml per hour for 3 hours,was administered immediately after inducing SAP through jugular vein.4.Known effective medicime group.Instead of HHI-Ⅰ Dan Shen Injection composite(DSHIco) was given at the same dosage as HHI-Ⅰ.10 rats in group 2,3,4 were sacrificed at 1,3,6,and 24 hour after treatment separately and pancreas and lung tissue samples were harvested for CD11b/CD18 examination using immunochemistry technique.Results: We could not detect any activities of CD11b/CD18 in pancreas.In group 2,the expression of CD11b/CD18in lung of rats began to increase at 3 hour after SAP.For rats in group 3,the activity of CD11b of lung markedly decreased at1hour after SAP(compared with group 2,4 P<0.05).Further decreasing was found at3,6,12 hours(P<0.01).Meanwhile,the CD18 expressions of lung in every time points were all decreased(compared with group 2,4 P<0.01).In group 4,similar changes of the expression of CD11b/CD18 of lung were not noticde.Conclusion: HHI-Ⅰ can significantly decline the increased expression of CD11b/CD18 of lung in SAP rats.DSHIco hasn't similar effect. |
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