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| Influence of High Lipid Serum on Expression of M-CSF mRNA in Mice Macrophage (Mφ) and Mudulafing Effect of Chinese Herbs with Regulating Liver and Removing Turbidity |
| Hits 1694 Download times 1002 Received:September 20, 2002 |
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| DOI
10.11656/j.issn.1673-9043.2002.04.26 |
| Key Words
M M-CSF Chinese herbs which can regulating the liver and removing the turbid ity AS |
| Author Name | Affiliation | | Luo Shuangxing | Tianjin Medical Collage, Tianjin 30005 | | Lu Yizhu | 天津中医学院 300193 | | Zhao Guifeng | 天津中医学院 300193 | | 范英昌 | 天津中医学院 300193 |
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| Abstract
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| Objective: To observe the influence of the high lipid serum on expression of the peritoneal M-CSF(macrophage-colony stimulating factor)mRNA in mice Mφ and to study the mudulating effect of Chinese herbs which can regulating the liver and removing the turbidity and its mechanism of preventing and treating AS(arteriosclerosis).Method: Mφ in the abdominal cavity fluid was harvested.Then RNA was obtained.The expression of M-CSF mRNA was observed with RT-PC R.Results: The expression of M-CSF mRNA in the high lipid group was enhanced obviously(in contrast with the normal group P<0.01).The expression in the Chinese herbs group was lower than in the model group,but higher than that in the normal group.Conclusion: The Chinese herbs,which can regulate the liver and removing the turbidity can control the expression of M-CSF mRNA and has a good effect on preventing and treating AS through this mechanism. |
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