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| Inhibition of Chinese material medica on vascular smooth muscle cell hyperplasia |
| Hits 2130 Download times 1825 Received:March 08, 2003 |
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| DOI
10.11656/j.issn.1673-9043.2003.02.11 |
| Key Words
Chinese material medica;vascular smooth muscle cell (VSMC);cellular culture;c-jun |
| Author Name | Affiliation | | WANG Wei | Tianjin Medical College, Tianjin 300052, China | | XU Zong-pei | 天津中医学院 300193 | | LIU Hong-yin | 天津肿瘤研究所 300200 | | 刘生 | 天津肿瘤医院 300204 |
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| Abstract
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| [Objective] To study the effect and mechanism of Chinese material medica on the inhibition of vascular smooth muscle cell (VSMC) hyperplasia. [Methods] 3H-TdR incorporation and expression of c-jun cDNA in VSMC was used. The growth and hyperplasia of VSMC were observed. [Results] The amount of 3H-TdR incorporation in serum+endothelin-1 with Chinese herbs group (cpm 1104.33±37.31/105 cell) was lowered than that in serum+endothelin-1 group (cpm 2S34.S4±54.22/105 cell) with a significant difference (P<0.01). And the c-jun mRNA expression of carcinoma insitu to was also weaker in the former group. [Conclusion] It shows that compound Danshen dripping pills can inhibit the hyperplasia of VAMC and c-jun mRNA expression of carcinoma insitu. |
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