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| Influence of chromosome X abnormity on development and function of human ovary |
| Hits 2204 Download times 2618 Received:March 20, 2003 |
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| DOI
10.11656/j.issn.1673-9043.2003.02.21 |
| Key Words
chromosome X;ovary;sex hormone |
| Author Name | Affiliation | | LI Guang | Tianjin Medical University, Tianjin 300070, China | | LI Ke-qiu | Tianjin Medical University, Tianjin 300070, China | | XING Hui-zhen | Tianjin Medical University, Tianjin 300070, China | | 王砚 | Tianjin Medical University, Tianjin 300070, China |
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| Abstract
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| [Objective] To probe into the genetic effect of chromosome X on the development and function of human ovary. [Methods] Twenty-eight patients with primacy or secondary or irregular amenorrhea due to numerical or structural abnormity of chromosome were analyzed. Their sex hormone was detected simultaneously. [Result] Seventeen cases belong to numerical abnormity and 11 cases to structural abnormity. FSH and LH in cases with 4S, XO were higher than in healthy person [t=19.565 (FSH), t=19.091(LH), P=0.000 (FSH,LH)]. They also higher than in other patients with numerical abnormity [t=4.531,P=0.012 (FSH); t=3.478, P=0.013 (LH)]. [Conclusion] Numerical or structural abnormity of chromosome X are the main causes of disturbance of ovary development and function. |
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