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| Effect of Weichangle on EGF and EGFR in rats with gastric ulcer induced by pyloric ligation |
| Hits 1877 Download times 1649 Received:April 05, 2004 |
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| DOI
10.11656/j.issn.1673-9043.2004.02.13 |
| Key Words
Weichangle;gastric ulcer;epidermal growth factor;epidermal growth factor receptor |
| Author Name | Affiliation | | PAN Hua-feng | The First Clinic Hospital of Guangzhou University of TCM, Guangzhou 510405, China | | ZHAO Xia | The First Clinic Hospital of Guangzhou University of TCM, Guangzhou 510405, China | | LIU You-zhang | The First Clinic Hospital of Guangzhou University of TCM, Guangzhou 510405, China | | 王茵萍 | 江苏省南京市人民医院 210029 |
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| Abstract
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| [Objective] To investigate the mechanism of anti-ulcer function and Protective effect to gastric mucosa cells of Weichangle (WCL).[Methods] Fourty-eight SD rats were divided randomly into 5 groups:normal group,model group,WCL high-dosage group,WCL middle-dosage group,WCL lowdosage group and omeptazole group.The index of ulcer (UI) was measured hy a vernier,the expression of epidermal growth factor (EGD and its receptor (EGFR) were detected by immunohistochemistry (SABC),and the microimagine was analysed by MPISA.[Result] The expression of EGF and EGFR in high and mild dosage group of WCL were obviously higher than those of the model group (P<0.05). [Conclusion] WCL has anti-ulcer effect and make the ulcer healed.The mechanisms maybe relate to its effect of Promoting the expression of EGF and EGFR,and thereby Protecting the gastric mucosa. |
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