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| Comparison of Influence of Natural Borneol and Synthetic Borneol onGastric Mucosal Barrier in Rats |
| Hits 1825 Download times 2181 Received:May 26, 2005 |
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| DOI
10.11656/j.issn.1673-9043.2005.03.05 |
| Key Words
natural borneol;svnthetic borneol;gastric mucosal barrier |
| Author Name | Affiliation | | HU Li-min | Tianjin University of TCM, Tianjin 300193, China | | FAN Guan-wei | Tianjin University of TCM, Tianjin 300193, China | | GAO Xiu-mei | Tianjin University of TCM, Tianjin 300193, China | | 张伯礼 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the influence of natural borneol (containingd-borneol) and synthetic borneol on gastric mucosal barrier.[Methods] Wistar rats were anaesthetized.Abdomen was opened and a small hole was (up on the stomach.One electrode and Laser Doppler Flowmeter probe were put into the stomach.To administrate Natural Borneol and Synthetic Borneol into the stomach respectively and provide aspirin and physiologic saline as (ontrol.To record and analyze the change of electrical potential difference across gastric mucosa (PD) and gastric mucosal blood flow (GMBF) by means of Powerlab electronic physiology graph and Laser Doppler Flowmeter in the before and after of administration.[Result] The rats of 0.2g/kg Synthetic Borneol group may degrade PD and GMBF in the stomach significantly.The effect was similar to that of 0.2g/kg Aspirin.While 0.2g/kg Natural Borneol did not cut down PD and GMBF significantly.[Conclusion] Synthetic Borneol had the effect of weakening the gastric mucosa barrier function.While Natural Borneol had less effect of weakening the gastric mucosa barrier function than Synthetic Borneol. |
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