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| Influence of Shanwei Prescription on P16 Protein in Atrophic Gastritis Patients in Precancer period with Deficiency of Both Qi and Yin |
| Hits 1854 Download times 1953 Received:November 30, 2005 |
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| DOI
10.11656/j.issn.1673-9043.2006.01.07 |
| Key Words
LIU Fang;pediatrics;academic thought |
| Author Name | Affiliation | | YANG You-xin | Tianjin University of TCM Tianjin 300193 China | | YUAN Hong-xia | Tianjin University of TCM Tianjin 300193 China | | YANG Man | 解放军272医院 300191 | | 代二庆 | 武警医学院附属医院 300040 | | 赵强 | 天津中医学院第一附属医院 300193 |
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| Abstract
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| [Objective]To observe the curative effect in patients with chronic atrophic gastritis (CAG) with deficiency of both Qi and Yin and observe the expression of antioncogene protein P16 integral score before and after treatment.[Methods]The selected patients were suffered from chronic atrophic gastritis (CAG) with gastric mucous membrane dysplasia (Dys) and/or intestinal metaplasia (IM) diagnosed by endoscopy and pathologic examination.Sixty patients were randomly divided into treatment group and control group.The patients of treatment group were administrated with Shanwei (invigorating the construction and function of stomach) prescription and the patients of control group with heriacium tablet for six months.[Result]The overall effective rate of treatment group and control group was 90.00% and 55.67% respectively.There was an obvious difference between the treatment group and control group (P<0.01).In the treatment group some obvious improvements in the atrophy extent,intestinal metaplasia and atypical hyperplasia were observed (P<0.05).The antioncogene protein P16 expression of treatment group was obviously higher than that of control group (P<0.05).[Conclusion]The Shanwei prescription has definite curative effect on chronic atrophic gastritis (CAG) with deficiency of both Qi and Yin and may reverse the pathologic change of the gastric mucous membrane on a certain extent by increasing the expression level of P16 protein probably. |
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