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| Experimental research with Benefiting stomach prescriptions expression of the revelant gene of the Precancerous of gastric cancer |
| Hits 1530 Download times 1726 Received:September 30, 2005 |
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| DOI
10.11656/j.issn.1673-9043.2006.01.08 |
| Key Words
gene protein;benefiting stomach prescriptions;test study |
| Author Name | Affiliation | | ZHUO Yu-zhen | Tianjin Univercity of TCM Tianjin 300193, China | | YUAN Hong-xia | Tianjin Univercity of TCM Tianjin 300193, China | | YUAN Hong-mei | 山东省邹平县中医院 200256 | | 王学 | 山东省邹平县中医院 200256 |
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| Abstract
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| [Objective] It is to observe the effect benefiting stomach prescriptions on chronic atrophic gastritis patients with dysplasis and (or) intestinal metaplasia,and the expression of relative gene of stomach mucous membrane tissue.[Methods] 154 cases of precancerous lesions of gastric cancer are divided into 2 groups at random,among which,106 cases in observation group (were given benefiting stomach prescriptions),the observation group is once more divided into 3 groups according to differentiation types,among which,34 cases in the pattern of blood stasis and heat toxicity (benefiting stomachⅠ),43 cases in the pattern of Yin deficiency with heat (benefiting stomachⅡ),29 cases in the pattern of Qi and Yin deficiency (benefiting stomach Ⅲ).48 cases in control group (were given Houtoujun tables),all patients in two groups were treated for 6 months.Research items include clinical manifestation,endoscope sign,tissue pathogenesis,and the expressive condition of relative gene of stomach mucous membrane tissue (ras primary cancer gene P21 and cancer suppressor gene P16) by immune histochemistry method.[Results] The total efficient is 83.96% in observation group; And 29.17% in control group,there was obviously difference between them,P<0.01;There were great improvement in the degree of gland atrophy、intestinal metaplasia、dysplasis of stomach mucous membrane tissue in observation group,P<0.01; and it was not obvious in control group; There is significant decrease in the expressive level of ras cancer gene P21 after treatment comparing with that before treatment, P<0.05; There is significant increase in the expressive level of cancer suppressor gene p16 after treatment comparing with that before treatment,P<0.05.[Conclusion] Chinese herb series of benefiting stomach prescriptions can properly adjust the expressive level of relative gene protein (P21,P16). |
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