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The influence of salvianolic acid B and tanshinone ⅡA on the nitric oxide and triglyceride in sera of atherosclerosis rabbits
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DOI   10.11656/j.issn.1673-9043.2006.01.14
Key Words   red sage root;salvianolic acid B;tanshinoneⅡA;atherosclerosis;nitric oxide;triglyceride
Author NameAffiliation
LV Bing-qiang Tianjin University of TCM Tianjin 300193 China 
FAN Ying-chang Tianjin University of TCM Tianjin 300193 China 
SUN Lian-sheng 天津市塘沽区杭州道医院 300354 
Abstract
    [Objective] To study the influence of water-soluble active principle (salvianolic acid B) and fat-soluble active principle (tanshinoneⅡA) on the level of nitric oxide (NO) and triglyceride (TG) in sera of atherosclerosis rabbits.[Methods] Atherosclerosis was initiated in rabbits by feeding cholesterol and oil.The influence of salvianolic acid B and tanshinoneⅡA on sera NO and TG were observed by radio immunity and GPO-PAP.[Results] Both of the salvianolic acid B and the tanshinoneⅡA could markedly decrease the level of TG and significantly increase the NOW but the tanshinoneⅡA was significantly better than the salvianolic acid B on NO,the salvianolic acid B was better significantly better than the tanshinoneⅡA on TG.[Conclusion] The salvianolic acid B and tanshinoneⅡA both could inhit atherogenesis of hyperlipid-fed rabbits by modulate the NO and TG,but the mechanism is not entire the same.

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