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| Effect of Tongmaijiangzhi Granula on Blood Fat and Hemorheology after Percutaneous Transluminal Coronary Angioplasty Operation |
| Hits 1598 Download times 1683 Received:June 17, 2006 |
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| DOI
10.11656/j.issn.1673-9043.2006.03.24 |
| Key Words
tongmaijiangzhi granular percutaneous transluminal coronary angioplasty (PTCA);cholesterin;triglyceride;hemorheology |
| Author Name | Affiliation | | ZHAO Ying-qiang | The Second Hospital Affiliated Tianjin University of TCM, Tianjin 300150, China | | SUN Lan-jun | The Second Hospital Affiliated Tianjin University of TCM, Tianjin 300150, China | | WANG Rui-hua | The Second Hospital Affiliated Tianjin University of TCM, Tianjin 300150, China | | 郑偕扣 | The Second Hospital Affiliated Tianjin University of TCM, Tianjin 300150, China |
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| Abstract
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| [Objective] To observe the effect of tongmaijiangzhi granules on blood fat and hemorheology after the percutaneous transluminal coronary angioplasty operation.[Methods] Sixty maleness Wistar rats were randomly divided into six groups(blank group, model group, high fat group, the prevenion group of tongmaijiangzhi granules, the prevenion group of tongxinluo capsule, the prevenion group of probucol). Except for the rats belong to blank group, every rat was fed to high fat feedstuff in three weeks. Before earring out percutaneous transluminal coronary angioplasty operation, we keep on feeding rats on medicine one week. We made the percutaneous transluminal coronary angioplasty rat model after one week. Then keep on feeding the rats to medicine three weeks. After three weeks, we gathered blood specimen and carried out chemical examination.[Results] There are conspicuous significance in the level of cholesterin, triglyceride between the blank group and model group(P<0.05). The result shows that the model is successful. There are conspicuous reduce in the level of cholesterin, triglyceride between the prevention group of tongmaijiangzhi grain and the model group (P<0.05). In blood viscosity and platelet aggregation rate aspect, there are obviously changes between the blank group and the model group (P<0.05), between the model group and the tongmaijiang zhigraian prevention group (P<0.05).[Conclusion] The experiment results shows that the tongmaijiangzhi grain has the function of suppressing the level of cholesterin, triglyceride, blood viscosity and platelet aggregation rate, has some extent function of preventing restenosis after the percutaneous transluminal coronary angioplasty operation. The tongmaijaingzhi grain is not harmful to the function of liver and kidney. |
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