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| Efffect of TanshinoneⅡA on on Vessel Diastolic and Systolic Factors of ECV304 Cell |
| Hits 1647 Download times 1944 Received:June 18, 2006 |
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| DOI
10.11656/j.issn.1673-9043.2006.04.11 |
| Key Words
Tanshinone ⅡA;EVC304;The diastolic and systolic factors of blood vessel;the radio immunoassay technology |
| Author Name | Affiliation | | FAN Ying-chang | Tianjin University of TCM, Tianjin 300193, China | | JIN Shu-mei | 天津市环湖医院 300050 | | ZHAO Gui-feng | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To illustrate the role of Tanshinone ⅡA (Tan ⅡA) which are extracted from dan-shen root in atherosclerosis (AS) and its different targets by investigating the effect on the diastolic and systolic factors of Human umbilical vascular endothelial cell 30 (4EVC304). [Methods] By establishing the model of TNF-α-induced cultured EVC304 cell,the radioimmunoassay and nitric reductase methods were used to analyze the content of the diastolic and systolic factors in the culture medium of the EVC304,which was cultured in different denses of Tan ⅡA.[Results] It was showed that the content of the diastolic factor such as NO was significantly enhanced by of Tan ⅡA and the content of the diastolic factors such as ET-1 and TXA2 were induced significantly (P<0.05 or P<0.01).But it was not effect on the content of the diastolic factor of PGI2.[Conclusion] Tan ⅡA has a significant effect on the diastolic and systolic factors to suppress the progression of AS. |
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