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| Feasibility of color doppler ultrasound in assessment of heart function in rat |
| Hits 1632 Download times 2840 Received:August 11, 2006 |
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| DOI
10.11656/j.issn.1673-9043.2007.01.12 |
| Key Words
color Doppler ultrasound;myocardial infarction;cardiac function of rat;hemodynamics |
| Author Name | Affiliation | | MA Xiao-yan | The Affiliated Hospital to Tianjin Academy of TCM, Tianjin 300120, China | | WANG Yi | 天津中医药大学 310193 | | XU Qiang | 天津中医药大学 310193 | | 高秀梅 | 天津中医药大学 310193 |
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| Abstract
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| [Objection] This study attempted to determine whether color Doppler ultrasound examination was available to evaluate the change of left ventricle structure and function in normal rats or rats with chronic heart failure through a comparison with the hemodynamic detection.[Methods] By ligating the left anterior descending coronary artery the chronic heart failure was induced in rats. Five to seven weeks after operation the heart function was measured with color Doppler ultrasound and invasive hemodynamic determination. Simultaneously, the parallel control experiment was performed.[Results] A perfect correlation was found between the value of EF and FS obtained with color ultrasound and LV peak +dp/dtmax determined with hymodynamic research in both normal and CHF rats(r=0.921 and r=0.827, respectively, P<0.01).[Conclusion] The noninvasive twodimensional color Doppler ultrasound at chest wall can assess the change of heart function and structure in rats with chronic cardiac failure substituting for the invasive hymodynamic evalustion. |
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