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| Effects of xuebijing injection on organ function and mortality in rats with sepsis |
| Hits 2181 Download times 2422 Received:February 02, 2007 |
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| DOI
10.11656/j.issn.1673-9043.2007.02.06 |
| Key Words
Xuebijing injection;sepsisf cecum ligation and puncture;organ functionf mortality |
| Author Name | Affiliation | | WU Zi-xia | Tianjian University of TCM, Tianjian 300193, China | | LI Yin-ping | Tianjin Tianhe Hospital, Tianjin 300050, China | | QIAO Youg-jie | Tianjin Tianhe Hospital, Tianjin 300050, China | | 姚咏明 | 解放军总医院第一附属医院(原解放军第三○四医院)全军烧伤研究所 100037 | | 于燕 | 解放军总医院第一附属医院(原解放军第三○四医院)全军烧伤研究所 100037 | | 吴瑶 | 解放军总医院第一附属医院(原解放军第三○四医院)全军烧伤研究所 100037 |
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| Abstract
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| [Objective] To investigate the effects of Xuebijing (cleaning the blood) injection on them ultiple organ function and mortality in ratswith sepsis.[Methods] Sepsis was reproduced in ratswith cecum ligation and puncture (CLP).Ninety-six male W istarratswererandom lydivided intonorm alcontrolgroup (n=8),sham-operation group (n=8),CLP model group (n=40),Xuebijing-treated group (n=40).The two latter groups were further divided into five groups of 2,8,24,48,and 72-hour subgroups with 8 ratsin each.In addition,another experiments were performed to observe the effect of treatment of Xuebijing on the survivalrate.[Results] Serum levels of ALT,AST,blood urea nitrogen (BUN),creatinine (Cr),creatine kinase (CK) and MB isoenzyme ofcreatine kinase (CK-MB) were significantly increased with certain extentat different intervals.Early treatment with Xuebijing could markedly improved serum biochemical param eterspartly.Treatm entwith Xuebijing or/and antibiotic could significantly improve the survivalrates in septic rats.[Conclusion] These finding sindicates that Xuebijing injection can obviously decline the mortality of septicrats,and hasplayed an important role in protecting against the multiple organ dysfunction. |
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