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Effect of Shanwei First Formula on regulating of PCNA of blood stagnation and pyretic toxicity syndrome of stomach precancerosis
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DOI   10.11656/j.issn.1673-9043.2007.03.09
Key Words   Shanwei First Formula;stomach precancerosis;PCNA;promoting blood flow and deintoxication
Author NameAffiliation
WANG Hong-jun Tianjin university of TCM, Tianjin 300193, China 
YUAN Hong-xia Tianjin university of TCM, Tianjin 300193, China 
TIAN Jing-jing Tianjin university of TCM, Tianjin 300193, China 
韩慧 Tianjin university of TCM, Tianjin 300193, China 
魏爱勤 Tianjin university of TCM, Tianjin 300193, China 
Abstract
    [Objective] To observe curative effect of TCM Shanwei first formula on regualting PCNA expression of blood stagnation and pyretic toxicity syndrome of stomach precancerosis patients.[Methods] The selected eighty-two patients were randomly divided into treatment group and control group.The patients of treatment group were adminstrated Shanwei first formula and that of treatment group were adminstrated heriacium tablet.The course of treatment was six months.[Results] The total effective rate of treatment group was 85.29%and that of control group was 29.17% (P<0.01).The improvement extent of atrophia,Intestinal metaplasia,atypical hyperplasia in treatment group was obviously higher than that in control group (P<0.01). The lower PCNA expression of treatment group was obviously better than that of control group (P<0.05).[Conclusions] Shanwei first formula may have a better curative and preventive effect of blood stagnation and pyretic toxicity syndrome of stomach precancerosis patients and may deteriorate atypical hyperplasia and decrease PCNA expression.

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