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| Effect of XinFuKang on left ventricular remodeling and enhancing angiogenesis after myocardial infarction in rats |
| Hits 1554 Download times 1729 Received:February 02, 2007 |
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| DOI
10.11656/j.issn.1673-9043.2007.03.12 |
| Key Words
XinFuKan;myocardial infarctio;angiogenesis |
| Author Name | Affiliation | | MA Wen-li | Tianjin University of TCM, Tianjin 300193, China | | GUO Ma-juan | Tianjin University of TCM, Tianjin 300193, China | | HUA Sheng-yu | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To study the impact of XinFuKang on left ventricular remodeling (LVRM) and angiogenesis after myocardial infarction (MI) in rats.[Methods] The model of myocardial infarction was induced by ligating the descending left coronary artery in male rats.Twentyfour hours later,48 survied rats with AMI were randomly divided into myocardial infarction control group,sham-operated group,Xinkukang middle dose group and Xinfukang high dose group.After four weeks of therapy,cardia tissue section were observed by immunohistochemistry.[Results] Compared to sham operated,Xinfukang high dose group can enhance angiogenesis and inhibit collagen fibers increased and disordered.[Conclusion] Xinfukang can prevent LVRM after MI in rats,prohibit collagen fibers hyperplasia and enhance angiogenesis. |
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