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| Effect of Jiashen prescription on the expression of AQP mRNA of cHF rats |
| Hits 1794 Download times 1484 Received:September 20, 2007 |
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| DOI
10.11656/j.issn.1673-9043.2007.04.08 |
| Key Words
Jiashen prescription;CHF;AQP |
| Author Name | Affiliation | | WANG Yi | Key Laboratory of Pharmacology of TCM Formulae, Ministry of Education Research Center of TCM, Tianjin University of TCM, Tianjin 300193, China | | GUO Zhi-jun | Key Laboratory of Pharmacology of TCM Formulae, Ministry of Education Research Center of TCM, Tianjin University of TCM, Tianjin 300193, China | | XU Qiang | Key Laboratory of Pharmacology of TCM Formulae, Ministry of Education Research Center of TCM, Tianjin University of TCM, Tianjin 300193, China | | 马晓艳 | Key Laboratory of Pharmacology of TCM Formulae, Ministry of Education Research Center of TCM, Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the effect of Jiashen prescription on the expression of AQP mRNA of CHF rats and explore the effect mechanism to improve water-sodium retention. [Methods] CHF(congestive heart failure) after myocardial infarction induced by ligation of an-terior descending coronary method in rats was established. They were randomly divided into three groups: Jiashen prescription group, model group and sham operated group. [Results] Jiashen prescription may decrease unusual increasing level of AVP and AQP-2mRNA expression of CHF rats and inhibit AVP-2R activation. [Conclusion] Jiashen prescription may regulate AQP-2mRNA expression of CHF rats, decrease water permeability of luminal liquid and water-sodium retention, promote evacuation of urine and cut down the volume load of heart. The effect mechanism of Jiashen prescription is probably related to strengthening heart function. |
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