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| Study of acupuncture prescription on CaN mRNA specific expression in SAMP10 brain |
| Hits 1664 Download times 1612 Received:November 02, 2007 |
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| DOI
10.11656/j.issn.1673-9043.2008.01.09 |
| Key Words
brain aging;calcineurin;XNKQ acupuncture method;senescence accelerated mouse |
| Author Name | Affiliation | | FAN Xiao-nong | Tianjin Research Institute of Acupuncture and Moxibustion, Tianjn Focal Point Laboratory of Acupuncture and Moxibustion, Tianjin 300193, China | | WEN Ting-yi | 中国科学院微生物研究所 100101 | | LIU Jian | Tianjin Research Institute of Acupuncture and Moxibustion, Tianjn Focal Point Laboratory of Acupuncture and Moxibustion, Tianjin 300193, China | | 杜元灏 | Tianjin Research Institute of Acupuncture and Moxibustion, Tianjn Focal Point Laboratory of Acupuncture and Moxibustion, Tianjin 300193, China | | 李平 | 天津市南开医院 300100 | | 王舒 | Tianjin Research Institute of Acupuncture and Moxibustion, Tianjn Focal Point Laboratory of Acupuncture and Moxibustion, Tianjin 300193, China | | 石学敏 | 天津中医药大学第一附属医院 300193 |
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| Abstract
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| [Objective] To know the effects of different acupuncture prescription on calcineurin (CaN) mRNA expression in senescence accelerated mouse P10 brain.[Method] Probe was labeled withα-32P-dCTP,mRNA expression was semiquantitatively analyzed with Northern blotting.The 8-month SAMP10 (model group) were respectively punctured with Xingnaokaiqiao (XNKQ) acupuncture method (reducing excess group) and reinforcing liver and kidney acupuncture method (reinforcing deficiency group).The points of XNKQ acupuncture method were Renzhong (DU 26) and Neiguan (PC 6),and that of reinforcing liver and kidney acupuncture method were Ganshu (BL 18) and Shenshu (BL 23).[Result] Compared with normal group,expression level of CaN mRNA decreased.XNKQ acupuncture method could increase CaN mRNA expression to approach normal level (P<0.05),and there was increase tendency in reinforcing liver and kidney acupuncture method (P>0.05).Therefore,XNKQ acupuncture method surpass reinforcing liver and kidney acupuncture method.[Conclusion] CaN mRNA expression decrease might be one of mechanisms in brain aging,acupuncture can increase CaN mRNA expression with prescription specificity.XNKQ acupuncture method might be potential tactic in treating brain aging. |
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