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| Study on excretion of periplocin in rats |
| Hits 2030 Download times 2000 Received:November 02, 2007 |
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| DOI
10.11656/j.issn.1673-9043.2008.01.11 |
| Key Words
Periplocin;feces;urine;bile;excretion;metabolite |
| Author Name | Affiliation | | WANG Qiang | Key Laboratory of the Pharmacology of Traditional Chinese Medical Formulae, Tianjin University of TCM, Tianjin 300193, China | | REN Xiao-liang | Key Laboratory of the Pharmacology of Traditional Chinese Medical Formulae, Tianjin University of TCM, Tianjin 300193, China | | Wang Yan | Key Laboratory of the Pharmacology of Traditional Chinese Medical Formulae, Tianjin University of TCM, Tianjin 300193, China | | 潘桂湘 | Key Laboratory of the Pharmacology of Traditional Chinese Medical Formulae, Tianjin University of TCM, Tianjin 300193, China | | 高秀梅 | Key Laboratory of the Pharmacology of Traditional Chinese Medical Formulae, Tianjin University of TCM, Tianjin 300193, China | | 戚爱棣 | Key Laboratory of the Pharmacology of Traditional Chinese Medical Formulae, Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To study on excretion of periplocin in rats.[Methods] A liquid-liquid extraction followed by high performance liquid chromatography (HPLC) method was used to detect the content of periplocin in feces,urine and bile of rats.Then the study of excretion after oral and intravenous administration was carried out.[Results] After oral administration Periplocin at a dose of 12mg/kg,the cumulative excretions of Periplocin and its conjugated metabolite in urine within 72h was 0.44%,and in feces the values of Periplocin and its hydrolytic metabolite was 12.39%.When administered intravenously at a dose of 0.74mg/kg,the cumulative excretions of Periplocin and its conjugated metabolite in urine within 72h was 6.24%,and in feces the values of Periplocin and its hydrolytic metabolite was 7.33%,and the cumulative excretions of Periplocin in bile within 21h was 76.13%.[Conclusion] Periplocin was mainly eliminated via bile,but hardly via feces and urine.And Periplocin was eliminated via feces and urine in the forms of its metabolites by intestinal bacteria (deduced as Periplocymarin),conjugated metabolites,respectively. |
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