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| Effect of xiaozheng injection on Fas and Survivin expression of ectopic endometrium in experimental endometriosis |
| Hits 1555 Download times 1407 Received:December 18, 2007 |
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| DOI
10.11656/j.issn.1673-9043.2008.02.06 |
| Key Words
Xiaozheng injection;endometriosis;Fas;Survivin;fluorescence quantitative PCR |
| Author Name | Affiliation | | CHEN Jin | Tianjin University of TCM, Tianjin 300193, China | | XIAO Mei-ru | 天津中医药大学第二附属医院 300150 |
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| Abstract
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| [Objective] To explore the mechanism of Xiaozheng(eliminating abdominal mass) injection in treating endometriosis. [Methods] The expression of Fas and Survivin gene of endometrium tissue in SD female rats with endometriosis was determined before and after treatment by fluorescence quantitative PCR. [Results] The Fas gene expression was low and the survivin gene expression was high in rats of model group. The apoptosispromoting ability was decreased in either normal or ectopic endometrium and the survival ability of the ectopic endometrium outsides the cavity pelvis was enhanced. All Xiaozheng injection and absolute alcohol may increase the Fas gene expression and decrease survivin gene expression after treatment. There wasn't obvious difference between two groups (P>0.05). But there was obvious difference between different dosage group of Xiaozheng injection (P<0.05). [Conclusion] Xiaozheng injection and absolute alcohol may increase Fas gene expression and decrease survivin gene expression which may lead to cell apoptosis of ectopic endometrium and therefore achieve the curative outcome for endometriosis. |
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