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| Effect of glucoperiplocymarin on left ventricular structure and function in chronic heart failure rats by color doppler-echocardiography |
| Hits 1494 Download times 1843 Received:December 02, 2007 |
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| DOI
10.11656/j.issn.1673-9043.2008.02.10 |
| Key Words
Glucoperiplocymarin;CHF;doppler-echocardiography;left ventricular structure and function |
| Author Name | Affiliation | | MA Li | The TCM Research Institute of Tianjin University of TCM, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin 300193, China | | JI Yan-su | The TCM Research Institute of Tianjin University of TCM, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin 300193, China | | HAN Juan | The TCM Research Institute of Tianjin University of TCM, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin 300193, China | | 李芳 | The TCM Research Institute of Tianjin University of TCM, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin 300193, China | | 王怡 | The TCM Research Institute of Tianjin University of TCM, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the effect of Glucoperiplocymarin on left ventricular structure and function in chronic heart failure(CHF)rats by Color Doppler-echocardiography. [Methods] The model of CHF was induced byligatingthe anterior descendingbranch of the left coronaryartery. The rats were at randomdivided intosixgroups: shamoperation group, model group, digoxin group, three treatment groups treated with 8 mg/kg, 4 mg/kg and 2 mg/kg dosage of Glucoperiplocymarin. After administration for 4 weeks, The effect of Glucoperiplocymarin treatment on LVDd, LVDs, LVSd, LVSs, LVPWd, LVPWs, EF, FS, LVEDV, LVESV, SV was observed. [Results] All the treated groups could decrease LVDd and LVDs in different degree, and there was significant difference between the Glucoperiplocymarin 8 mg/kg dosage treated group、digoxin group and model group (P<0.05, P<0.01);All the treated groups could increase EF、FS and decrease LVEDV and LVESV. Compared with model group, EF and LVESV of the Glucoperiplocymarin 8 mg/kg、4 mg/kg dosage treated group and FS of the Glucoperiplocymarin 8mg/kg dosage treated group had significant difference (P<0.05, P<0.01). [Conclusion] Glucoperiplocymarin could improve the left ventricular structure and function in chronic heart failure rats. There was a trend that the effects of 8mg/kg dose group of the Glucoperiplocymarin were better than others. |
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