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| Development and overview of pharmacokinetics study for fifty years |
| Hits 1508 Download times 2029 Received:June 06, 2008 |
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| DOI
10.11656/j.issn.1673-9043.2008.03.03 |
| Key Words
pharmacokinetics;basic theory;basic method;the pharmacokinetics of Chinese herbal medicine;difficulty and hot spot of pharmacokinetics study;metabolism group study; complicated system |
| Author Name | Affiliation | | LIU Chang-xiao | The Co-constructive Key Laboratory of Pharmacokinetics and Pharmacodynamics by Education Ministry and Tianjin Medicine Institute
The Institute of Traditional Chinese Medicine of Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| The aim of this article was summing up the development history of pharmacokinetics study for fifty years based on the angle of development.The development of pharmacokinetics was reviewed and the application and important role on the basic theory and method of pharmacokinetics study were analyzed.For example,the application of pharmacokinetics study could involve in clinical therapeutics, clinical pharmacology,experimental pharmacology,biology,molecular pharmacology,biochemistry and toxicology,etc.The pharmacokinetics study played an important role on the new medicine study and research,included the drug design,pharmaceutics and quality control of medicine,etc.The national development history of pharmacokinetics study and the contribution on the concept,principle,method and application of pharmacokinetics were summed up.The pharmacokinetics study of Chinese herbal medicine introduced a new topic for the pharmacokinetics and was a very difficult and complicated subjects.Since 1980,the pharmacokinetics study of Chinese herbal medicine achieved a obvious progression and indicated a plenty of new theory and method.The course of development included three development stage.The first stage of pharmacokinetics study was carrying out physiological disposition of active component study from 1949 to 1970.The second stage of pharmacokinetics study was a quickly developing stage on the pharmacokinetics study from 1970 to 1990.The third stage was the formation of pharmacokinetics after 1990.The study of metabolism group increased the development of pharmacokinetics study.The difficulty and hot spot of pharmacokinetics study were analyzed and thought that the method and technology of metabolism group study could enhance the research level of the traditional Chinese medicine. |
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