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| General reproduction toxicity of Bis oxovanadium(α-furan carboxylato) combining with liuweidihuang pills in normal mice |
| Hits 1416 Download times 1750 Received:August 18, 2008 |
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| DOI
10.11656/j.issn.1673-9043.2008.04.10 |
| Key Words
VO-FA;Liuweidihuang Pills;reproduction toxic effect;experimental study |
| Author Name | Affiliation | | FENG Li | Tianjin University of TCM, Tianjin 300193, China | | YANG Lin | Tianjin University of TCM, Tianjin 300193, China | | WANG Yu-Chun | Tianjin University of TCM, Tianjin 300193, China | | 谢明进 | 南开大学 300071 | | 阎世平 | 南开大学 300071 | | 范英昌 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the reproduction toxicity of the Bis oxovanadium (α-furan carboxylato) (VO-FA) combining with Liuweidihuang Pills (LW) on normal mice.[Methods] Three different doses of VO-FA and three combining LW groups were supplied to normal mice. The female and male mice were gathered in one cage for copulation according to 1:1 proportion.Before copulation,medicine was given to the male continuously for 40 d and the female for 20 d.Medicine was given continuously for another 6d after copulation.The mice general condition,the change of the body weight and the reproduction index were observed.[Results] Besides the lowered activity observed in higher dosage of VO-FA female and male mice,the condition of organism in other group was not abnormal.The reproduction index of the male mice was normal.Besides the group with higher dosage of VO-FA,the body weight in other groups increased obviously compared with the normal group.Except the lower copulation time,and lowered pregnancy number and pregnancy rate in the higher dosage of VO-FA,no significant differences were seen in other groups.Compared with the higher dosage of VO-FA the pregnancy rate in all each groups had significant difference but normal group.In the production index of embryo mice,besides the lower number of living embryo in higher dosage of VO-FA,no significant difference was observed in each group.[Conclusion] The higher dosage of VO-FA has some influence on the activity of female and male mice,copulation time,the number of pregnancy mice as well as the number of living embryo.No obvious reproduction toxic effect was observed in this group in the study on the general reproduction toxicity. |
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