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| Pharmacokinetic study of berberine hydrochloride of cortex phellodendri in rat plasma |
| Hits 2266 Download times 3265 Received:May 24, 2008 |
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| DOI
10.11656/j.issn.1673-9043.2008.04.12 |
| Key Words
HPLC;cortex phellodendri;berberine hydrochloride;pharmacokinetics |
| Author Name | Affiliation | | XIAO Xue-feng | Tianjin University of TCM, Tianjin 300193, China | | QIAO Xiao-li | 天津市南开医院 300191 | | GAO Lan | Tianjin University of TCM, Tianjin 300193, China | | 孙瑜 | Tianjin University of TCM, Tianjin 300193, China | | 张军平 | 天津中医药大学第一附属医院 300193 |
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| Abstract
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| [Objective] To study pharmacokinetics of berberine hydrochloride in Cortex Phel-lodendri in the rat.[Methods] Use HPLC to determine serum concentrations of berberine hy-drochloride in Cortex Phellodendri in rat pLasma.The pharmacokinetic parameters of berberine hydrochloride was fitted with 3p97 procedure.[Result] The pharmacokinetic parameters of berberine hydrochloride in Cortex Phellodendri were AUC=774.3 (mg·L)/min,Ke=7.285×10-3 L/min, Ka=4.166×10-2 L/min,T1/2 (Ka)=16.64 min,T1/2 (Ke)=95.15 min,T (peak)=50.73 min,C (max)=3.898 mg/L.[Conclusion] The berberine hydrochloride in Cortex Phellodendri showed one-compartment in the body of Wistar rats. |
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