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| Effect of FangXiaoLing Capsule on serum IFN-γ and IL-4 Content in asthma rats |
| Hits 1702 Download times 1761 Received:December 19, 2008 |
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| DOI
10.11656/j.issn.1673-9043.2009.02.11 |
| Key Words
FangXiaoLing capsule;invigorating the kidney and excreting dampness;asthma;rat;cell factor;IFN-γ;IL-4 |
| Author Name | Affiliation | | XUE Wei-lin | Qingdao Hiser Medical Center, Qingdao Hospital of TCM, Qingdao 266033, China | | ZHOU Zhao-shan | Qingdao Hiser Medical Center, Qingdao Hospital of TCM, Qingdao 266033, China | | JIANG Wen-qing | Qingdao Hiser Medical Center, Qingdao Hospital of TCM, Qingdao 266033, China | | 张作仕 | Qingdao Hiser Medical Center, Qingdao Hospital of TCM, Qingdao 266033, China | | 解春霞 | Qingdao Hiser Medical Center, Qingdao Hospital of TCM, Qingdao 266033, China | | 王镜銮 | Qingdao Hiser Medical Center, Qingdao Hospital of TCM, Qingdao 266033, China | | 胡海波 | Qingdao Hiser Medical Center, Qingdao Hospital of TCM, Qingdao 266033, China |
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| Abstract
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| [Objective] To observe the effect of FangXiaoLing capsule on serum IFN-γand IL-4 content in asthma rats and explore the effect mechanism of FangXiaoLing capsule in treating air passage of asthma.[Methods] Eighty-four Wistar rats were randomly divided into seven groups with 12 rats per group.The model of asthma in rats was established by using egg protein method.The serum IFN-γand IL-4 content of rats in each group were determined by ELISA method.[Results] The serum IFN-γcontent of B group was obviously lower than that of normal group (P<0.05).But serum IL-4 content of B group was obviously higher than that of normal group (P<0.05).An obvious unbalance between IFN-γ/IL-4 proportion was existed.All treatment group had up-regulation of IFN-γ and down-regulation of IL-4 level at different extent and the C group had the most obviously curative effect.It was noticed that the effect tendency of FangXiaoLing capsule may be strengthened obviously with the increasing of administration dosage or intervention in advance according to the change of the correction unbalance of IFN-γ/IL-4 extent.[Conclusion] The effect mechanism of FangXiaoLing capsule may be correlated with the correcting unbalance of IFN-γ/IL-4 ratio. |
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