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| Protection effect of salvianolic acids B against liver injury in rats with passive cigarette smoking |
| Hits 1820 Download times 1815 Received:March 12, 2009 |
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| DOI
10.11656/j.issn.1673-9043.2009.03.11 |
| Key Words
salvianolic acids B;passive smoking;liver injury |
| Author Name | Affiliation | | GAN Ping | Tianjin High Special School of Medicine, Tianjin 300222, China | | NIE Gui-li | Tianjin High Special School of Medicine, Tianjin 300222, China | | LI Ai-shan | Tianjin High Special School of Medicine, Tianjin 300222, China |
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| Abstract
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| [Objective] To discuss the protection effect and the mechanism of salvianolic acids B in the development of live injury in rats with passive cigarette smoking.[Methods] Wistar rats were randomly divided into 3 groups: normal group, smoking group and salvianolic acids B prevention group. The content of serum ALT, AST and LDH in every group was assayed and the changing of MDA's content and the activity of SOD in serum and hepatic tissue were analyzed.[Results] Compared with the normal group, the MDA's content in the hepatic tissue and AST, ALT, LDH and MDA's content in the serum increased obviously in smoking group. The activity of the SOD decreased (P<0.01). After treating with salvianolic acids B, the MDA's content in the hepatic tissue and the content of AST, ALT, LDH and MDA decreased. The activity of SOD increased (P<0.05) compared with the smoking group.[Conclusion] Salvianolic acids B can provide adequate protection against the rats' liver injury caused by passive smoking. Its mechanism may be related to the anti-oxygen free radical injury. |
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