|
| Effect of tangziqing on lipid metabolism in mice with diabetes mellitus induced with alloxan |
| Hits 2603 Download times 2323 Received:October 11, 2009 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2009.04.08 |
| Key Words
alloxan;mice with diabetes mellitus;Tangzhiqng;metabolism of sugar and lipid |
| Author Name | Affiliation | | LI Yu-hong | The Institute of Chinese Materia Medica of TCM University
The Key Laboratory of Pharmacology of Chinese Herbs
The Key Laboratory of Prescriptions of Educational Ministry, Tianjin 300193, China | | ZHANG De-qin | The Institute of Chinese Materia Medica of TCM University
The Key Laboratory of Pharmacology of Chinese Herbs
The Key Laboratory of Prescriptions of Educational Ministry, Tianjin 300193, China | | LIU Hong | The Institute of Chinese Materia Medica of TCM University
The Key Laboratory of Pharmacology of Chinese Herbs
The Key Laboratory of Prescriptions of Educational Ministry, Tianjin 300193, China | | 王茜 | The Institute of Chinese Materia Medica of TCM University
The Key Laboratory of Pharmacology of Chinese Herbs
The Key Laboratory of Prescriptions of Educational Ministry, Tianjin 300193, China | | 李俊青 | The Institute of Chinese Materia Medica of TCM University
The Key Laboratory of Pharmacology of Chinese Herbs
The Key Laboratory of Prescriptions of Educational Ministry, Tianjin 300193, China |
|
| Abstract
|
| [Objective] To explore the pharmacologic effect of Tangzhiqing for decreasing sugar and regulating lipid to provide a experimental evidence for the clinical application.[Methods] The 2% solution of alloxan,200 mg/kg,was injected into mice intraperitoneally to induce the onset of diabetes mellitus.Fasting blood glucose (FBG) was measured 72 h later.More than 11 mmol/L was taken as the success criteria of model establishing.Taking metformin as the control the effect of Tangzhiqing on the fasting blood glucose and the blood lipid was observed after 30 days for serial intragastric infusion of the drug with 8,4 and 2 g/kg of crude drug.[Results] Tangzhiqing could improve the developmental condition of the mice with diabetes mellitus,decrease the FBG and serum triglyceride (TG) in these mice,ameliorate the pathologic change of pancreas and liver.[Conclusion] Tanghiqing has good therapeutic effect on mice with diabetes mellitus induced with alloxan. |
|
|
|
|
|
