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| Effect of sitian acupoint prescription on periphery inflammatory factor and matrix metalloproteinase expression in rats with disease of vertebrae cervicales |
| Hits 1955 Download times 2156 Received:September 11, 2009 |
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| DOI
10.11656/j.issn.1673-9043.2009.04.09 |
| Key Words
Sitian acupoints prescription;disease of vertebrae cervicales;inflammatory factor;MMP-3;SABC method |
| Author Name | Affiliation | | ZHOU Zhen | The Second Hospital Affiliated to Tianjin University of TCM, Tianjin 300150, China | | WANG Zun-lai | 天津市北辰区北门医院 300400 | | WANG Xiu-yun | 天津中医药大学 300193 | | 孟向文 | 天津中医药大学 300193 | | 尚秀葵 | 天津中医药大学 300193 | | 董洪英 | 天津中医药大学 300193 |
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| Abstract
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| [Objective] To discuss the effective mechanism of Sitian acupoints prescription in treating disease of vertebrae cervicales of rats through observing IL-1β,iNOS,COX-2 and MMP-3 expression change.[Methods] Sixty Wistar rats were randomly divided into four groups:sham operated group, model group,Sitian acupoint acupuncture group,Jiaji acupoint group.The disease of vertebrae cervicales induced by imbalance of dynamic-static force was established.Treating with Sitian acupoint and jiaji acupoint was given for 4 days.IL-1,iNOS,COX-2 MMP-3 enzyme and MMP-3 protein were determined by SABC method.1,2 and 4 weeks after disease.[Results] Sitian acupoint prescription could obviously inhibit IL-1β,iNOS,COX-2 and MMP-3 protein expression.[Conclusion] Sitian acupoint prescription may retard the retrograde change of cervical intervertebral disk and its effective mechanism might be related with inhibiting the periphery inflammatory factor and MMP-3 protein expression. |
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