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| Effect of phycocyanin on the expression of NFkB and IkB in islet cells of Type 2 diabetic mellitus in rats |
| Hits 1673 Download times 1829 Received:December 11, 2009 |
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| DOI
10.11656/j.issn.1673-9043.2010.01.10 |
| Key Words
phycocyanin;diabetes mellitus;NFκB;IκB;rats |
| Author Name | Affiliation | | ZHANG Rui | Teaching and Research Center of Integrated Medicine, Qingdao University Medical College, Qingdao 266021, China | | MA Xuan | Teaching and Research Center of Integrated Medicine, Qingdao University Medical College, Qingdao 266021, China | | LIU Lin | Teaching and Research Center of Integrated Medicine, Qingdao University Medical College, Qingdao 266021, China | | 刘吉东 | 中国科学院海洋研究所 266071 | | 沈卫 | Teaching and Research Center of Integrated Medicine, Qingdao University Medical College, Qingdao 266021, China |
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| Abstract
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| [Objective] To investigate the effect and action mechanism of phycocyanin on the function of islet cells of rats with diabetic mellitus.[Methods] A model of Type 2 diabetes mellitus was induced by high fat diet and intraperitoneal injection of streptozotocin (STZ) in low dose in 32 healthy male Wistar rats. They were treated with phycocyanin and dimethylbiguanide. The expression of nuclear factors B (NFκB) and inhibitory κB (IκB) in islet cells was detected by immunohistochemistry.[Results] The free blood glucose (FBG) in model group was significantly higher than that in rats of normal control group, and was significantly lower in treated groups compared with model group (P<0.05) .The expressions of NFκB protein increased while IκB protein decreased significantly in islet cells of model group rats. After treatment with phycocyanin and dimethylbiguanide, the NFκB protein expressed lowly and IκB protein expressed highly than those in model group rats. (P<0.05).[Conclusion] It is suggested that phycocyanin may inhibit the activity of IκB/NFκB pathway to protect the islet cells of diabetic mellitus in rats. |
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