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| Effect of ginkgo biloba extract EGB761 on permeability of Blood-brain barrier in rabbits with hypercholesterolemia |
| Hits 1751 Download times 2099 Received:December 11, 2009 |
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| DOI
10.11656/j.issn.1673-9043.2010.01.11 |
| Key Words
ginkgo biloba extract EGB761;Blood-brain barrier;hypercholesterolemia;permeability |
| Author Name | Affiliation | | WANG Qiang | Tianjin University of TCM, Tianjin 300193, China | | JIANG Xi-juan | Tianjin University of TCM, Tianjin 300193, China | | FAN Ying-chang | Tianjin University of TCM, Tianjin 300193, China | | 张瑞峰 | Tianjin University of TCM, Tianjin 300193, China | | 郭茂娟 | Tianjin University of TCM, Tianjin 300193, China | | 马东明 | Tianjin University of TCM, Tianjin 300193, China | | 卢斌 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe whether Ginkgo biloba extract EGB761 can offer protection for Blood-brain barrier.[Methods] The male adult New Zealand rabbits were fed by 2% high cholesterol feed in order to establish the model of hypercholesterolemia in rabbitss. After that EGB761 was used to treat the rabbits at a dose of 50 mg/(kg·d) for 3 weeks and simvastatin, 5 mg/(kg·d), as a positive control drug . All the animals were injected by EB, 25 g/L, through auricle vein. 3 hours later, all animals were anaesthetized, and drawn sample after perfusion by normal saline. Finally, the content of EB in cortex, hippocampus and olfactory bulb was tested by means of colorimetric method.[Results] The content of EB in hippocampus and olfactory bulb was reduced by Ginkgo biloba extract EGB761, and they were P<0.01, P<0.05 compared with model group, which was not significant different compared to the effect of positive drug simvastatin (P<0.05).[Conclusion] Ginkgo biloba extract EGB761 can reduce Blood-brain barrier impairment caused by hypercholesterolemia. |
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