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| Effect of huatan tongluo therapy combined with urokinase thrombolysis on PAF`MCP-1 in different brain regions in rats with acute cerebral infarction |
| Hits 1796 Download times 1829 Received:December 14, 2009 |
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| DOI
10.11656/j.issn.1673-9043.2010.01.13 |
| Key Words
huatan tongluo therapy;thrombolysis;PAF;MCP-1;eLISA Method;recurrence of infarction |
| Author Name | Affiliation | | ZHOU Zhen | The Second Affiliated Hospital of TCM, Tianjin 300150, China | | ZHANG Yu-lian | The Second Affiliated Hospital of TCM, Tianjin 300150, China | | GUO Jia-kui | The Second Affiliated Hospital of TCM, Tianjin 300150, China | | 王占奎 | The Second Affiliated Hospital of TCM, Tianjin 300150, China | | 刘爽 | 天津中医药大学 300193 | | 张琳琳 | 天津中医药大学 300193 |
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| Abstract
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| [Objective] To observe the effect of Huatan(resolving phlegm) Tongluo(dredging collateral) therapy combined with urokinase thrombolysis on the PAF, MCP-1 in different brain regions in rats with acute cerebral infarction and investigate the action mechanism of recurrence of infarction of intravenous thrombolysis in rats.[Methods] 136 SD rats were divided into 5 groups randomly: normal group, sham operation group, model group, urokinase group, Huatan Tongluo Therapy combined with urokinase thrombolysis group. We made middle cerebral artery occlusion model in rats by using their own embolus, and treated by gavage with Chinese herbs and urokinase thrombolysis respectively. Then we observed the expression of PAF, MCP-1 in the rat brain tissue with ELISA method after acute cerebral infarction (6 h,72 h,7 d,14 d). [Result] Huatan Tongluo Therapy combined with urokinase thrombolysis could inhibit the expression of PAF, MCP-1 obviously.[Conclusion] Chinese herbs combined with thrombolysis therapy can reduce the probability of recurrence of infarction with intravenous thrombolysis, and the action mechanism might be related to inhibiting the expression of PAF and MCP-1. |
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