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| Effects of piperine on convulsive seizures induced by kainic acid |
| Hits 1535 Download times 1714 Received:December 20, 2009 |
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| DOI
10.11656/j.issn.1673-9043.2010.02.13 |
| Key Words
piperine;experimental epilepsy;kainic acid |
| Author Name | Affiliation | | CUI Guang-zhi | Tianjin University of TCM, Tianjin 300193, China | | JIN Shu-mei | 天津市环湖医院 300060 |
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| Abstract
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| [Objective] To study the effects of piperine on several experimental epilepsy models and analyze it's mechanisms.[Methods] Experimental epilepsy in mice and rabbits was induced.The concentration of amino acid was determined by automatic analyzer in brain of mice.The releasing experiment of glutamic acid in cortex slice of rats was performed.[Results] Piperine had obvious antagonism against clonospasm induced by KA (icv) in mice,the ED50 was 24.0 mg/kg.It could also prolong the latency of abnormal ECoG and decrease the continued time of abnormal ECoG induced by intrahippocampal injection of KA in rabbits.Piperine could reduce the levels of Glu and Asp in mice brain,so it could also decrease the Glu+Asp/GABA ratio.It could not alter the levels of GABA.Piperine (10-6 mol) It could obviously decrease the release of proloaded [3H]-Glu evoked by high (k+) in cortex slice in rat.[Conclusion] Piperine has a potent antagonistic effect on experimental epilepsy in mice and rabbits.The mechanism of the anticonvulsant action of piperine is related to the function of EAA in central nerve system. |
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