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| Effect of curcumin,berberine and its compatibility on glucose and lipid metabolism in db/db mice |
| Hits 2805 Download times 2200 Received:April 01, 2010 |
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| DOI
10.11656/j.issn.1673-9043.2010.03.10 |
| Key Words
curcumin;berberine;compatibility;db/db mice;glucose and lipid metabolism |
| Author Name | Affiliation | | GAO Yan | Tianjin University of TCM, Tianjin Laboratory of Chinese Medience Pharmachology, Tianjin 300193, China | | CUI Guang-zhi | Tianjin University of TCM, Tianjin Laboratory of Chinese Medience Pharmachology, Tianjin 300193, China | | LI Hui-ying | Tianjin University of TCM, Tianjin Laboratory of Chinese Medience Pharmachology, Tianjin 300193, China | | 张艳军 | Tianjin University of TCM, Tianjin Laboratory of Chinese Medience Pharmachology, Tianjin 300193, China | | 刘洋 | Tianjin University of TCM, Tianjin Laboratory of Chinese Medience Pharmachology, Tianjin 300193, China |
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| Abstract
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| [Objection] To observe the effect of curcumin,berberine and its compatibility on glucose and lipid metabolism in db/db mice,and provide experimental basis for the rationality of compatibility.[Methods] Curcumin,berberine and combined application of both were orally administrated to the db/ db mice for 28 days,to observe the effect of body weight,organ coefficient,based glucose,glucose tolerance curve,CHO,TG,HDL-C and LDL-C in db/db mice.[Results] All treated groups can significantly reduce the db/db mice liver coefficient (P<0.05) ,curcumin low-dose (19.5 mg/kg) berberine high-dose (144 mg/kg) compatibility group and curcumin high-dose (39 mg/kg) berberine high-dose (144 mg/kg) compatibility group can significantly reduce the db/db mice serum-based glucose (P<0.05) ,curcumin low-dose (19.5 mg/kg) berberine high-dose (144 mg/kg) compatibility group and curcumin high-dose (39 mg/kg) berberine high-dose (144 mg/kg1) compatibility group can significantly improve and regulate the glucose tolerance curve of db/db mice (P<0.05) ,curcumin low-dose (19.5 mg/kg) group,curcumin high-dose (39 mg/kg) berberine low-dose (72 mg/kg) compatibility group and curcumin low-dose (19.5 mg/ kg) berberine high-dose (144 mg/kg) compatibility group can significantly reduce the level of the TG in db/db mice (P<0.05).[Conclusion] The compatibility of curcumin with berberine can significantly improve the glucose and lipids metabolism disorders of the db/db mice to a certain extent,and its effect better than the separate administration group,and curcumin low-dose (19.5 mg/kg) berberine high-dose (144 mg/kg) compatibility group integrated to show a more significant effect. |
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