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| Effect of Xinnao Xuemaining on reducing plaque hematoma and stable plaques of vulnerable plaque in rabbits with atherosclerosis |
| Hits 1326 Download times 1780 Received:February 11, 2011 |
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| DOI
10.11656/j.issn.1673-9043.2011.01.12 |
| Key Words
Xinnao Xuemaining;vulnerable plaque;neovascularization;platelet derived growth factor receptor;pericytes |
| Author Name | Affiliation | | JIANG Xijuan | Tianjin University of TCM, Tianjin 300193, China | | MA Dongming | Tianjin University of TCM, Tianjin 300193, China | | LU Bin | Tianjin University of TCM, Tianjin 300193, China | | 杨琳 | Tianjin University of TCM, Tianjin 300193, China | | 宋石林 | Tianjin University of TCM, Tianjin 300193, China | | 范英昌 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the effects of Xinnao Xuemaining on reducing plaque hematoma and the expression of PDGFR of vulnerable plaque in rabbits with atherosclerosis.[Methods] The vulnerable atherosclerotic plaque model was reproduced by operation on abdominal aorta endothelium for inducing sacculus pull injury with the foraging with high cholesterol lipid feeding.Ribbits were divided into three groups:model group,sham operation group and Xinnao Xuemaining group.The experiment lasted for 15 weeks.After killing at the end of experiment,the sample of abdominal aorta was collected for HE staining and microscopic lesion examination,counting of the number of plaque hematoma and detecting the protein content of PDGFR by immunohistochemistry.[Results] HE observation was found 6 rabbits of the 12 plaque hematoma in model group,and three rabbits,three plaque hematoma in Xinnao Xuemaining group.The new blood vessels lacked pericytes surrounded,and after the intervention of Xinnao Xuemaining,pericytes surrounded the new blood vessels increased.The results of immunohistochemical staining showed that the expression of platelet derived growth factor receptor in Xinnao Xuemaining group enhanced significantly compared with model group (P<0.01).[Conclusion] Xinnao Xuemaining can reduce plaque hematoma of vulnerable plaque in rabbits with atherosclerosis and promote plaque neovascularization mature,whose mechanism may be related to increased expression of PDGFR and raised on pericytes. |
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