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| Influence of Qiliqiangxin capsule on cardiac function in rats with chronic heart failure of Heart Qi deficiency |
| Hits 1603 Download times 1732 Received:January 11, 2011 |
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| DOI
10.11656/j.issn.1673-9043.2011.01.13 |
| Key Words
Qiliqiangxin capsule;Heart Qi deficiency;chronic heart failure;cardiac function |
| Author Name | Affiliation | | LI Xintong | Tianjin University of TCM, Tianjin 300193, China | | XIAO Yang | Tianjin University of TCM, Tianjin 300193, China | | XING Yongfa | Tianjin University of TCM, Tianjin 300193, China | | 王怡 | Tianjin University of TCM, Tianjin 300193, China | | 于春泉 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objection] To observe the effect of Qiliqiangxin capsule on the structure of left ventricular structure and function in rats with chronic heart failure (CHF) of Heart Qi deficiency and its effect on the syndrome of Heart Qi deficiency.[Methods] The anterior descending coronary artery was ligated in rats,CHF was caused by myocardial infarction and Heart Qi deficiency was formed after 8 weeks after that.The rats were randomly divided into sham operation group,model group,Qiliqiangxin capsule of 0.25,0.5,1.0 g/kg group,and valsartan group.After treating for 4 weeks the heart rate,respiratory rate,exhaustive swimming time was evaluated and the echocardiography instrument was used to measure the left ventricular function and structure.[Results] Qiliqiangxin capsule could improve the heart rate,respiratory rate and swimming time in different degrees.It could also decrease LVDd,LVDs,LVEDV,LVESV,while increasing LVSd,LVSs,LVPWd,LVPWs and EF,FS in different degrees. There were significant differences between the Qiliqiangxin capsule and model group (P<0.05,P<0.01).[Conclusion] Qiliqiangxin capsule can improve the symptoms of heart Qi deficiency,ameliorate the abnormality of the ventricular cardiac structure,and increase the heart function of CHF with heart Qi deficiency in rats.High dose group of Qiliqiangxin capsule is more superior than other dose groups. |
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