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| Effects of curcumin,berberine and its compatibility on mRNA expression of glucose and lipid metabolismrelated genes in db/db mice |
| Hits 1621 Download times 1917 Received:February 01, 2011 |
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| DOI
10.11656/j.issn.1673-9043.2011.01.14 |
| Key Words
curcumin;berberine;compatibility;db/db mice;glucose and lipid metabolism |
| Author Name | Affiliation | | GAO Yan | Tianjin University of TCM, Tianjin baboratory of Chinese medicnce phormachology, Tianjin 300193, China | | CUI Guangzhi | Tianjin University of TCM, Tianjin baboratory of Chinese medicnce phormachology, Tianjin 300193, China | | LI Huiying | Tianjin University of TCM, Tianjin baboratory of Chinese medicnce phormachology, Tianjin 300193, China | | 张艳军 | Tianjin University of TCM, Tianjin baboratory of Chinese medicnce phormachology, Tianjin 300193, China | | 刘洋 | Tianjin University of TCM, Tianjin baboratory of Chinese medicnce phormachology, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the effects of curcumin,berberine and its compatibility on mRNA expression of glucose and lipid metabolism-related genes in db/db mice and provide the experimental basis for the rational compatibility.[Methods] The db/db mice were orally administered with curcumin and berberine for 28 days.Real Time RT-PCR was used to detect G-6-Pase LDLR and AGF mRNA expression in liver.[Results] Treating db/db mice with curcumin,berberine and its compatibility,curcumin low-dose (19.5mg/kg),berberine high-dose (144mg/kg) could down-regulate the expression of LDLR in liver,but without significant effect on AGF mRNA.[Conclusion] Compatibility of berberine and curcumin,may regulate the expression of glucose and lipid metabolism-related genes mRNA and its effects are better than the separated administration group. |
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